Docs / Encryption & encoding
SHA256 is an AMPscript function in the encryption & encoding category.
SHA256(str, [charset])
%%=SHA256("ampsend")=%%
79335fa2590bb8c92d5d40973b27dbbc8c958a7eeb5d8cf36e1eef40751afa41
Output produced by AmpSend's AMPscript engine (validated against Salesforce's own test corpus) - not a hand-written result.
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SHA256 in the official AMPscript reference - or browse the official index of AMPscript functions for platform behavior and edge cases.