Docs / Data extensions
DeleteDE is an AMPscript function in the data extensions category.
DeleteDE(de, numKeys, keyCol, keyVal, ...)
%%[ DeleteDE("Loyalty", 1, "EmailAddress", "bob@example.com") ]%%
Rows after delete: %%=DataExtensionRowCount("Loyalty")=%%
Rows after delete: 1
Output produced by AmpSend's AMPscript engine (validated against Salesforce's own test corpus) - not a hand-written result.
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DeleteDE in the official AMPscript reference - or browse the official index of AMPscript functions for platform behavior and edge cases.