Docs / Data extensions
UpsertDE is an AMPscript function in the data extensions category.
UpsertDE(de, numKeys, keyCol, keyVal, ..., col, value, ...)
%%[ UpsertDE("Loyalty", 1, "EmailAddress", "new@example.com", "Tier", "Bronze") ]%%
Rows after upsert: %%=DataExtensionRowCount("Loyalty")=%%
Rows after upsert: 3
Output produced by AmpSend's AMPscript engine (validated against Salesforce's own test corpus) - not a hand-written result.
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UpsertDE in the official AMPscript reference - or browse the official index of AMPscript functions for platform behavior and edge cases.