Docs / Data extensions
Lookup is an AMPscript function in the data extensions category. First match; null when no match (IsNull is True), matching SFMC.
Lookup(de, returnCol, col, value, [col2, value2, ...])
%%=Lookup("Loyalty", "Tier", "EmailAddress", emailaddr)=%%
Gold
Output produced by AmpSend's AMPscript engine (validated against Salesforce's own test corpus) - not a hand-written result.
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Lookup in the official AMPscript reference - or browse the official index of AMPscript functions for platform behavior and edge cases.