Docs / Data extensions
UpdateDE is an AMPscript function in the data extensions category.
UpdateDE(de, numKeys, keyCol, keyVal, ..., col, value, ...)
%%[ UpdateDE("Loyalty", 1, "EmailAddress", emailaddr, "Tier", "Platinum") ]%%
New tier: %%=Lookup("Loyalty", "Tier", "EmailAddress", emailaddr)=%%
New tier: Platinum
Output produced by AmpSend's AMPscript engine (validated against Salesforce's own test corpus) - not a hand-written result.
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UpdateDE in the official AMPscript reference - or browse the official index of AMPscript functions for platform behavior and edge cases.